Former Bush Chief of Staff Andy Card is “seriously considering” a bid for the open Massachusetts Senate seat, according to a close friend and adviser.

Card is meeting Wednesday night with Bay State Republicans at their regular committee meeting in suburban Boston, said Ron Kaufman, Massachusetts Republican committeeman and a longtime associate of the former top Bush aide.

Kaufman said Card is being pushed by state Republicans to consider the special election to replace the late former Sen. Ted Kennedy and will likely decide by this weekend...