The devastating news that Barack Obama and his party lost a huge special election Tuesday night  --  in the staunch Democrat congressional district of the disgraced Anthony Weiner  --  effectively ends the presidency of Obama.  Even in what is probably the most ineffective United States Senate in American history  --  controlled by Harry Reid's Democrats  --  nothing of import will be passed by that chamber.
 
Some Democrats deserted Democrat candidate David Weprin before the election such as former New York City mayor Ed Koch.  He endorsed last night's Republican winner, businessman Bob Turner, last week. Within the next few months, the desertions by members of Obama's own party for his agenda are expected to dramatically increase.  Obama's agenda is effectively dead on arrival in the United States House of Representatives with the exception of tax cuts.
 
Democratic pollster and Fox News commentator Doug Schoen told NewsMax.com that the Republican win in the heart of Democratic liberalism represents a "stunning rebuke" to President Obama and his policies.  Schoen said, "It will be at the very least a wake-up call that every Democrat is potentially at risk."
 
Democrat Senators such as Ben Nelson from Nebraska; Claire McCaskill from Missouri; Joe Manchin from West Virginia; Robert Casey from Pennsylvania; and Jon Tester from Montana may all lose their seats in next year's election.  They are highly unlikely to support Obama's newest $450 billion stimulus ("jobs") bill or much else on Obama's agenda during the next 14 months.  Republicans will likely pick up the open seats now occupied by Democrat Senators Kent Conrad from North Dakota and James Webb from Virginia who resigned rather than face angry voters again.
 
But it gets worse for Obama.  Open seats now occupied by Senate Democrats in Wisconsin and New Mexico could very conceivably go Republican next year.  Finally, Democrat Senators Bill Nelson from Florida, Maria Cantwell from Washington and Amy Klobuchar could be defeated by strong Republican candidates.  That is a total of 12 seats which the Democrats could lose.  There is precedent.  When Governor Ronald Reagan was elected president in 1980, 16 new Republican Senators were elected with him.
 
Those are a lot of seats which could turn over to the Republicans in November 2012.  The Republicans need only 4 of these 12 endangered Democrat Senate seats to assume majority control of the United States Senate.  There are few political analysts who believe the Democrats will maintain control of the Senate.  Last night's huge loss in New York and landslide Republican victory in Nevada effectively kills Obama's agenda and thus his presidency.